Polimorfismos del gen IL28B no se asocian con el riesgo de infección por HTLV-1: un metaanálisis
IL28B y riesgo de infección por HTLV-1
DOI:
https://doi.org/10.47993/gmb.v48i2.1027Palabras clave:
interleucinas, metaanálisis, polimorfismo de nucleótido simple, Virus Linfotrópico T Humano tipo 1Resumen
Introducción: La búsqueda de factores genéticos de riesgo es importante para comprender la susceptibilidad al Virus Linfotrópico T Tipo 1 Humano (HTLV-1), aunque los polimorfismos del gen IL28B se han asociado con el riesgo de infección en otros virus, su papel en el riesgo de infección por HTLV-1 permanece incierto. Objetivo: Determinar si los polimorfismos de un solo nucleótido (SNP) rs8099917 y rs12979860 del gen IL28B están asociados con el riesgo de infección HTLV-1. Material y métodos: Se realizó un metaanálisis de estudios de casos y controles, se efectúo una búsqueda en Pubmed, Google Scholar y Scopus. Se extrajeron frecuencias genotípicas de los polimorfismos. Mediante un metaanálisis de asociación genética empleando el programa Metagenyo, se estimaron odds ratios (OR) e intervalos de confianza al 95% para cuatro modelos genéticos. Resultados: Se incluyeron cuatro estudios, constituyendo 875 participantes para el rs12979860 y 718 para rs8099917. No se observó desviación del equilibrio Hardy-Weinberg (p>0,05). No se evidenció asociación estadísticamente significativa de rs12979860 con riesgo de infección por HTLV-1 (modelo alélico: OR= 0,98; p= 0,89; modelo recesivo: OR= 1,03; p=0,85; modelo dominante: OR= 0,91; p= 0,63; modelo sobredominante OR= 0,92; p= 0,59); ni del rs8099917 (modelo alélico: OR= 1,01; p=0,97; modelo recesivo: OR= 0,95; p=0,78; modelo dominante: OR= 1,09; p=0,80; modelo sobredominante: OR= 1,12; p=0,53). Conclusión: El metaanálisis muestra que los SNPs rs8099917 y rs12979860, no están asociados con el riesgo de infección por HTLV-1. Se resaltan la necesidad de más investigaciones de tipo caso-control que permitan contrastar nuestra conclusión.
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