Manifestaciones Oftalmológicas en Pacientes con COVID 19

Daniela Mabel Rahib Sanabria

Autores/as

Daniela Mabel Rahib Sanabria Práctica privada.Cochabamba, Bolivia

Palabras clave:

COVID-19, SARS-CoV-2, Oftalmopatías

Resumen

La enfermedad por SARS-CoV-2 o COVID-19 es una patología nueva y sobre la que aún falta mucho por conocer, este virus puede afectar diferentes sistemas y órganos, por lo que, con el objetivo de conocer las manifestaciones oftalmológicas descritas hasta ahora en estos pacientes, se realizó una búsqueda sistemática de la literatura en PubMed-Medline y Google Scholar con las palabras clave <<COVID-19>> <<SARS-CoV-2>> <<Eye Diseases>> obteniendo un total de 471 artículos, de los cuales se seleccionaron 31. Se encontró que la principal manifestación oftalmológica es la conjuntivitis, que puede estar hasta en un 10% de los pacientes. Se encontraron reportes de manifestaciones neuroftalmológicas, principalmente las parálisis oculomotoras así mismo se han descrito casos de oclusiones vasculares. Los casos reportados sugieren un neurotropismo viral y mecanismos de lesión endotelial como causantes de estos cuadros.

Métricas

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Biografía del autor/a

Daniela Mabel Rahib Sanabria, Práctica privada.Cochabamba, Bolivia

Especialista en oftalmología

Citas

Parasher A. COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment. Postgraduate Medical Journal. 2021;97(1147):312-20.

Cruz-Durán A, Fernández-Garza NE. Fisiopatología de la COVID-19. Lux Médica. 2021;16(47). Disponible en: https://revistas.uaa.mx/index.php/luxmedica/article/view/3155 [citado 13 de junio de 2021]

Escalera-Antezana JP, Lizon-Ferrufino NF, Maldonado-Alanoca A, Alarcón-De-la-Vega G, Alvarado-Arnez LE, Balderrama-Saavedra MA, et al. Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain. Travel Med Infect Dis. 2020;35:101653.

Lee YH, Kim YC, Shin JP. Characteristics of Ocular Manifestations of Patients with Coronavirus Disease 2019 in Daegu Province, Korea. J Korean Med Sci. 2020;35(35). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476796/ [citado 10 de junio de 2021]

Sindhuja K, Lomi N, Asif MI, Tandon R. Clinical profile and prevalence of conjunctivitis in mild COVID-19 patients in a tertiary care COVID-19 hospital: A retrospective cross-sectional study. Indian J Ophthalmol. 2020;68(8):1546-50.

Aggarwal K, Agarwal A, Jaiswal N, Dahiya N, Ahuja A, Mahajan S, et al. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. PLoS One. 2020;15(11):e0241661.

Sen M, Honavar SG, Sharma N, Sachdev MS. COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19. Indian Journal of Ophthalmology. 2021;69(3):488-509.

Ma N, Li P, Wang X, Yu Y, Tan X, Chen P, et al. Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China. JAMA Ophthalmology. 2020;138(10):1079-1086. Disponible en: https://doi.org/10.1001/jamaophthalmol.2020.3690 [citado 10 de junio de 2021]

Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmologica. 2020;98(8):e951-9.

Atum M, Boz AAE, Çakır B, Karabay O, Köroğlu M, Öğütlü A, et al. Evaluation of Conjunctival Swab PCR Results in Patients with SARS-CoV-2 Infection. Ocular Immunology and Inflammation. 2020;28(5):745-8.

Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;138(5):575-8.

Hong N, Yu W, Xia J, Shen Y, Yap M, Han W. Evaluation of ocular symptoms and tropism of SARS-CoV-2 in patients confirmed with COVID-19. Acta Ophthalmologica. 2020;98(5):e649-55.

Zhou Y, Duan C, Zeng Y, Tong Y, Nie Y, Yang Y, et al. Ocular Findings and Proportion with Conjunctival SARS-COV-2 in COVID-19 Patients. Ophthalmology. 2020;127(7):982-3.

Rodríguez-Rodríguez MS, Romero-Castro RM, Alvarado-de la Barrera C, González-Cannata MG, García-Morales AK, Ávila-Ríos S. Optic neuritis following SARS-CoV-2 infection. J Neurovirol. 2021;27(2):359-63.

Sharma A, Kudchadkar US, Shirodkar R, Usgaonkar UPS, Naik A. Unilateral inferior altitudinal visual field defect related to COVID-19. Indian Journal of Ophthalmology. 2021;69(4):989-91.

Deane K, Sarfraz A, Sarfraz Z, Valentine D, Idowu AR, Sanchez V. Unilateral Optic Neuritis Associated with SARS-CoV-2 Infection: A Rare Complication. Am J Case Rep. 2021;22:e931665.

Selvaraj V, Sacchetti D, Finn A, Dapaah-Afriyie K. Acute Vision Loss in a Patient with COVID-19. R I Med J (2013). 2020;103(6):37-8.

Falcone MM, Rong AJ, Salazar H, Redick DW, Falcone S, Cavuoto KM. Acute abducens nerve palsy in a patient with the novel coronavirus disease (COVID-19). J AAPOS. 2020;24(4):216-7.

Pascual-Goñi E, Fortea J, Martínez-Domeño A, Rabella N, Tecame M, Gómez-Oliva C, et al. COVID-19-associated ophthalmoparesis and hypothalamic involvement. Neurol Neuroimmunol Neuroinflamm. 2020;7(5). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357415/ [citado 9 de junio de 2021]

Ordás CM, Villacieros-Álvarez J, Pastor-Vivas A-I, Corrales-Benítez Á. Concurrent tonic pupil and trochlear nerve palsy in COVID-19. J Neurovirol. 2020;1-3.

Faucher A, Rey P-A, Aguadisch E, Degos B. Isolated post SARS-CoV-2 diplopia. Journal of Neurology. 2020;267(11):3128–9. Disponible en: https://dx.doi.org/10.1007%2Fs00415-020-09987-x

Belghmaidi S, Nassih H, Boutgayout S, El Fakiri K, El Qadiry R, Hajji I, Bourrahouate A, Moutaouakil A. Third Cranial Nerve Palsy Presenting with Unilateral Diplopia and Strabismus in a 24-Year-Old Woman with COVID-19. PubMed.. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33056942/ [citado 6 de junio de 2021]

Belghmaidi S, Nassih H, Boutgayout S, El Fakiri K, El Qadiry R, Hajji I, et al. Third Cranial Nerve Palsy Presenting with Unilateral Diplopia and Strabismus in a 24-Year-Old Woman with COVID-19. American Journal of Case Reports. 2020;2121:e925897. Disponible en:

https://doi.org/10.12659/AJCR.925897

García-Romo E, Blanco R, Nicholls C, Hernández-Tejero A, Fernández-de-Arévalo B. COVID-19 presenting with nystagmus. Arch Soc Esp Oftalmol (Engl Ed). 2021;96(4):224-6.

Ortiz-Seller A, Martínez Costa L, Hernández-Pons A, Valls Pascual E, Solves Alemany A, Albert-Fort M. Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19). Ocular Immunology and Inflammation. 2020;28(8):1285-9.

Ilhan B, Cokal BG, Mungan Y. Intracranial hypertension and visual loss following COVID-19: A case report. Indian J Ophthalmol. 2021;69(6):1625-7.

Pérez Álvarez ÁI, Suárez Cuervo C, Fernández Menéndez S. Infección por SARS-CoV-2 asociada a diplopía y anticuerpos antirreceptor de acetilcolina. Neurología. 2020;35(4):264-5.

Ozsaygılı C, Bayram N, Ozdemir H. Cilioretinal artery occlusion with paracentral acute middle maculopathy associated with COVID-19. Indian J Ophthalmol. 2021;69(7):1956-9.

Yahalomi T, Pikkel J, Arnon R, Pessach Y. Central retinal vein occlusion in a young healthy COVID-19 patient: A case report. American Journal of Ophthalmology Case Reports. 2020;20:100992.

Walinjkar JA, Makhija SC, Sharma HR, Morekar SR, Natarajan S. Central retinal vein occlusion with COVID-19 infection as the presumptive etiology. Indian J Ophthalmol. 2020;68(11):2572-4.

Raval N, Djougarian A, Lin J. Central retinal vein occlusion in the setting of COVID-19 infection. Journal of Ophthalmic Inflammation and Infection. 2021;11(1):10.

Venkatesh R, Reddy NG, Agrawal S, Pereira A. COVID-19-associated central retinal vein occlusion treated with oral aspirin. BMJ Case Rep. 2021;14(5):e242987.

Invernizzi A, Pellegrini M, Messenio D, Cereda M, Olivieri P, Brambilla AM, et al. Impending Central Retinal Vein Occlusion in a Patient with Coronavirus Disease 2019 (COVID-19). Ocular Immunology and Inflammation. 2020;28(8):1290-2.

Gaba WH, Ahmed D, Nuaimi RKA, Dhahani AAA, Eatmadi H. Bilateral Central Retinal Vein Occlusion in a 40-Year-Old Man with Severe Coronavirus Disease 2019 (COVID-19) Pneumonia. Am J Case Rep. 20201029;21:e927691-1-e927691-5.

Gascon P, Briantais A, Bertrand E, Ramtohul P, Comet A, Beylerian M, et al. Covid-19-Associated Retinopathy: A Case Report. Ocular Immunology and Inflammation. 2020;28(8):1293-7.

Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection. Eye (Lond). 2020;34(12):2352-3.

Majtanova N, Kriskova P, Keri P, Fellner Z, Majtan J, Kolar P. Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases. Medicina (Kaunas). 2021;57(5):412.

Li M, Yang Y, He T, Wei R, Shen Y, Qi T, et al. Detection of SARS-CoV-2 in the ocular surface in different phases of COVID-19 patients in Shanghai, China. Annals of Translational Medicine. 2021;9(2):100. Disponible en: https://dx.doi.org/10.21037%2Fatm-20-6026. [citado 10 de junio de 2021]

Belser JA, Rota PA, Tumpey TM. Ocular Tropism of Respiratory Viruses. Microbiol Mol Biol Rev.2013;77(1):144-56.

Guzmán RR, Miranda EMC, Castillo NS, Guzmán-Díaz P, Dorta-Contreras AJ. Lesión endotelial, inmunología y neurotropismo en la fisiopatología de las complicaciones de los pacientes con la COVID-19. Revista Cubana de Investigaciones Biomédicas. 2021;40(2). Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/1130 [citado 13 de junio de 2021]

Zapata MÁ, García SB, Sánchez-Moltalvá A, Falcó A, Otero-Romero S, Arcos G, et al. Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity. British Journal of Ophthalmology. 2020; Disponible en: https://bjo.bmj.com/content/early/2021/01/21/bjophthalmol-2020-317953. [citado 10 de junio de 2021]