Use of enteric probiotics to reduce the incidence and severity of necrotizing enterocolitis in very low birth weight preterm newborns in the neonatal intensive care unit of the "Germán Urquidi" maternity hospital.
Use of enteral probiotics to reduce the incidence and severity of necrotizing enterocolitis
Keywords:
prematurity, enterocolitis, probioticosAbstract
At birth the neonatal intestinal tract is sterile; as the human intestine is exposed to the contaminated environment it is colonized by mostly favorable nonpathogenic bacteria, such as lactobacillus and bifidobacteria. In contrast, the intestine of the preterm newborn tends to be colonized by pathogenic microorganisms, predominantly coliforms, enterococci and bacteroides, species that increase the risk of developing necrotizing enterocolitis.
The aim of this study was to evaluate the effectiveness and efficacy of enteral probiotics to prevent necrotizing enterocolitis in preterm newborns.
A prospective, controlled, randomized, blinded, prospective study was carried out. Very low birth weight preterm infants were selected for the study. The patients were divided into two groups. The infants in the study group received PROBIOTICS with milk twice a day until they were discharged, the infants in the control group only received milk; the evolutionary parameters investigated were the presence of enterocolitis and death.
There were 68 preterm newborns of very low birth weight, 34 in the study group and 34 in the control group; the clinical and evolutionary variables showed significant differences between the two groups. The incidence of necrotizing enterocolitis was lower in the study group (2/34 vs. 16/34) and there were 4 cases of severe necrotizing enterocolitis (Bell's stage III) in the control group vs. none in the study group.
Enterally administered probiotics reduce the incidence and severity of necrotizing enterocolitis.
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