Experience in Partial Nephrectomy and Enucleation of Laparoscopic Renal Tumor "Zero ischemia", in Cochabamba, Bolivia
DOI:
https://doi.org/10.47993/gmb.v45i1.367Keywords:
renal cancer, laparoscopy, heminephrectomy , enucleation techniqueAbstract
Objectives: To determine oncologic outcomes in terms of tumor free edges and surgical complications in patients undergoing laparoscopic "Zero ischemia" partial nephrectomy and renal tumor enucleation.
Methodology: Retrospective, observational, and comparative study, who underwent laparoscopic partial nephrectomy, were grouped into two groups: Group I: partial nephrectomy and Group II: enucleation, were analyzed: size and location of the tumor, RENAL score, surgical time, bleeding, days of stay, complications and histopathological report.
Results: 17 patients were evaluated, 3 were excluded due to radical surgery, 6 partial (Group I) and 8 enucleations (Group II). Mean age 45.7 (± 8.6) vs 51.2 (± 6.3) years. Tumor size 7.8 (2.5-10) vs 3.2 (1-5.7) cm, The overall RENAL score of all patients was low to moderate. There were differences in favor of group II (enucleation) in terms of surgical time and transoperative bleeding. As for surgical edges, there were 2 (14.2%) cases with positive edges, 1 for each approach, which are kept under close surveillance.
Conclusions: the laparoscopic approach is an option comparable to the open approach; equal results were obtained in terms of oncologic control in relation to free edges and with fewer complications.
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References
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: A Cancer Journal for Clinicians. 2018;68(1):7–30. Disponible en: https://doi.org/10.3322/caac.21442.
Moch H, Gasser T, Amin MB, et al. Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer. 2000 Aug 1;89(3):604-14.
Leibovich BC, Lohse CM, Crispen PL, et al. Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. J Urol. 2010;183(4):1309-15. Disponible en: https://doi.org/10.1016/j.juro.2009.12.035.
Choyke PL, Glenn GM, Walther MM, et al. Hereditary renal cancers. Radiology. 2003;226(1):33-46. Disponible en: https://doi.org/10.1148/radiol.2261011296.
DeVita VT Jr HS, Rosenberg SA. Cancer Principies and Practice of Oncology. (ed 8th). Philadelphia, PA: Lippincott Williams & Wilkins;2008.
National Cancer Institute. “SEER Cancer Stat Facts.” Surveillance, Epidemiology, and End Results Program, 2018; Disponible en: https://seer.cancer.gov/statfacts/.
Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Disponible en: https://seer.cancer.gov/csr/1975_2014/.
Ficarra V, Schips L, Guille F, et al. Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma. Cáncer. 2005;104(5):968-74. Disponible en: https://doi.org/10.1002/cncr.21254.
Ljungberg B, Bensalah K, Canfield S, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol. 2015;67(5):913-24. Disponible en: https://doi.org/10.1016/j.eururo.2015.01.005.
Campbell SC, Novick AC, Belldegrun A, et al.Practice Guidelines Committee of the American Urological Association: Guideline for management of the clinical T1 renal mass. J Urol. 2009;182(4):1271-9. Disponible en: https://doi.org/10.1016/j.juro.2009.07.004.
Herr HW. A history of partial nephrectomy for renal tumors. J Urol. 2005;173(3):705-8. Disponible en: https://doi.org/10.1097/01.ju.0000146270.65101.1d.
Nieder AM, Taneja SS. The role of partial nephrectomy for renal cell carcinoma in contemporary practice. Urol Clin North Am. 2003;30(3):529-42. Disponible en: https://doi.org/10.1016/s0094-0143(03)00018-1.
Poulakis V, Witzsch U, de Vries R, et al. Quality of life after surgery for localized renal cell carcinoma: comparison between radical nephrectomy and nephron-sparing surgery. Urology. 2003;62(5):814-20. Disponible en: https://doi.org/10.1016/s0090-4295(03)00687-3.
Van Poppel H, Joniau S. Is surveillance an option for the treatment of small renal masses? Eur Urol. 2007;52(5):1323-
Disponible en: https://doi.org/10.1016/j.eururo.2007.07.025.
Thompson RH, Boorjian SA, Lohse CM, et al. Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy. J Urol. 2008;179(2):468-71. Disponible en:https://doi.org/10.1016/j.juro.2008.04.050.
Huang WC, Elkin EB, Levey AS, et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors--is there a difference in mortality and cardiovascular outcomes?. J Urol. 2009;181(1):55-61. Disponible en: https://doi.org/10.1016/j.juro.2008.09.017.
Thompson RH, Lane BR, Lohse CM, et al. Renal function after partial nephrectomy: effect of warm ischemia relative to quantity and quality of preserved kidney. Urology. 2012;79(2):356-60. Disponible en: https://doi.org/10.1016/j.urology.2011.10.031.
Van Poppel H, Da Pozzo L, Albrecht W, et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol. 2011;59(4):543-52. doi: Disponible en: https://doi.org/10.1016/j.eururo.2010.12.013.
Liss MA, Wang S, Palazzi K, et al. Evaluation of national trends in the utilization of partial nephrectomy in relation to the publication of the American Urologic Association guidelines for the management of clinical T1 renal masses. BMC Urology. 2014;14(1). Disponible en: https://dx.doi.org/10.1186%2F1471-2490-14-101.
Gill IS, Kavoussi LR, Lane BR, et al. Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors. J Urol. 2007;178(1):41-6. Disponible en: https://doi.org/10.1016/j.juro.2007.03.038.
Lane BR, Gill IS. 7-year oncological outcomes after laparoscopic and open partial nephrectomy. J Urol. 2010;183(2):473-9. Disponible en: https://doi.org/10.1016/j.juro.2009.10.023.
Gong EM, Orvieto MA, Zorn KC, et al. Comparison of laparoscopic and open partial nephrectomy in clinical T1a renal tumors. J Endourol. 2008;22(5):953-7. Disponible en: https://doi.org/10.1089/end.2007.0300.
Kutikov A, Uzzo RG. The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009;182(3):844-53. Disponible en: https://doi.org/10.1016/j.juro.2009.05.035.
Ficarra V, Novara G, Secco S, et al. Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery. Eur Urol. 2009;56(5):786-
Disponible en: https://doi.org/10.1016/j.eururo.2009.07.040.
Simmons MN, Ching CB, Samplaski MK, et al. Kidney tumor location measurement using the C index method. J Urol. 2010;183(5):1708-13. Disponible en: https://doi.org/10.1016/j.juro.2010.01.005.
Simmons MN, Hillyer SP, Lee BH, et al. Nephrometry score is associated with volume loss and functional recovery after partial nephrectomy. J Urol. 2012;188(1):39-44. Disponible en: https://doi.org/10.1016/j.juro.2012.02.2574.
Spaliviero M, Poon BY, Karlo CA, et al. An Arterial Based Complexity (ABC) Scoring System to Assess the Morbidity Profile of Partial Nephrectomy. Eur Urol. 2016;69(1):72-9. Disponible en: https://doi.org/10.1016/j.eururo.2015.08.008.
Mir MC, Campbell RA, Sharma N, et al. Parenchymal volume preservation and ischemia during partial nephrectomy: functional and volumetric analysis. Urology. 2013;82(2):263-8. Disponible en: https://doi.org/10.1016/j.urology.2013.03.068.
Castaneda CV, Danzig MR, Finkelstein JB, et al. The natural history of renal functional decline in patients undergoing surveillance in the DISSRM registry. Urol Oncol. 2015;33(4):166.e17-20. Disponible en: https://doi.org/10.1016/j.urolonc.2014.11.016.
Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296-305. Disponible en: https://doi.org/10.1056/NEJMoa041031.
Zargar H, Allaf ME, Bhayani S, et al. Trifecta and optimal perioperative outcomes of robotic and laparoscopic partial nephrectomy in surgical treatment of small renal masses: a multi-institutional study. BJU Int. 2015 Sep;116(3):407-14. Disponible en: https://doi.org/10.1111/bju.12933.
Uzzo RG, Novick AC. Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol. 2001;166(1):6-18.
Russo P. Open partial nephrectomy. Personal technique and current outcomes. Arch Esp Urol. 2011;64(7):571-93.
Kaouk JH, Khalifeh A, Hillyer S, et al. Robot-assisted laparoscopic partial nephrectomy: step-by-step contemporary technique and surgical outcomes at a single high-volume institution. Eur Urol. 2012;62(3):553-61. Disponible en: https://doi.org/10.1016/j.eururo.2012.05.021.
Gupta GN, Boris RS, Campbell SC, et al. Tumor Enucleation for Sporadic Localized Kidney Cancer: Pro and Con. J Urol. 2015;194(3):623-5. Disponible en: https://doi.org/10.1016/j.juro.2015.06.033.
Blackwell RH, Li B, Kozel Z, et al. Functional Implications of Renal Tumor Enucleation Relative to Standard Partial Nephrectomy. Urology. 2017;99:162-168. Disponible en: https://doi.org/10.1016/j.urology.2016.07.048.
Carini M, Minervini A, Masieri L, Lapini A, Serni S. Simple enucleation for the treatment of PT1a renal cell carcinoma: our 20-year experience. Eur Urol. 2006;50(6):1263-8. Disponible en: https://doi.org/10.1016/j.eururo.2006.05.022.
Mukkamala A, Allam CL, Ellison JS, et al. Tumor enucleation vs sharp excision in minimally invasive partial nephrectomy: technical benefit without impact on functional or oncologic outcomes. Urology. 2014;83(6):1294-9. Disponible en: https://doi.org/10.1016/j.urology.2014.02.007.
Longo N, Minervini A, Antonelli A, et al. Simple enucleation versus standard partial nephrectomy for clinical T1 renal masses: perioperative outcomes based on a matched-pair comparison of 396 patients (RECORd project). Eur J Surg Oncol. 2014;40(6):762-8. Disponible en: https://doi.org/10.1016/j.ejso.2014.01.007.
Minervini A, Campi R, Sessa F, et al. Positive surgical margins and local recurrence after simple enucleation and standard partial nephrectomy for malignant renal tumors: systematic review of the literature and meta-analysis of prevalence. Minerva Urol Nefrol. 2017;69(6):523-538. Disponible en: https://doi.org/10.23736/s0393-2249.17.02864-8.
Rais-Bahrami S, Guzzo TJ, Jarret TW, et al. Incidentally discovered renal masses: oncological and perioperative outcomes in patients with delayed surgical intervention. BJU Int. 2009;103(10):1355-8. Disponible en: https://doi.org/10.1111/j.1464-410x.2008.08242.x.
Dong W, Lin T, Li F, et al. Laparoscopic Partial Nephrectomy for T1 Renal Cell Carcinoma: Comparison of Two Resection Techniques in a Multi-institutional Propensity Score-Matching Analysis. Ann Surg Oncol. 2016;23(4):1395-402. Disponible en: https://doi.org/10.1245/s10434-015-4985-2.
Minervini A, di Cristofano C, Lapini A, et al. Histopathologic analysis of peritumoral pseudocapsule and surgical margin status after tumor enucleation for renal cell carcinoma. Eur Urol. 2009;55(6):1410-8. Disponible en: https://doi.org/10.1016/j.eururo.2008.07.038.
Schiavina R, Serni S, Mari A, et al. A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma: the RECORd1 Italian Project. Clin Genitourin Cancer. 2015;13(2):165-70. Disponible en: https://doi.org/10.1016/j.clgc.2014.08.008.
García AG, León TG. Simple Enucleation for Renal Tumors: Indications, Techniques, and Results. Curr Urol Rep. 2016;17(1):7. Disponible en: https://doi.org/10.1007/s11934-015-0560-4.
Dindo D, Demartines N, Clavien PA .Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. Disponible en: https://doi.org/10.1097/01.sla.0000133083.54934.ae.
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