Base deficit and lactate depuration in pediatric septic patient
Baseline deficit and lactate clearance in pediatric sepsis
Keywords:
sepsis, septic shock, lactate, base deficitAbstract
Sepsis and septic shock generate a state of microcirculatory failure, hipoxia and anaerobic metabolism and products like lactic acid and other organic acids are released; which lead to a deficit of bases.
Objective: this study aims to estimate the correlation of serum lactate and base deficit as guides in the management of septic shock during the first 24 hours.
Method: a prospective observational study; performing serial measurement hours 0, 6, 12 and 24 of lactate and base deficit; in patients with the same scheme of treatment for septic shock recommended by the CSS 2013.
Results:the serum lactate and base deficit were modified with resuscitation with a clearance of 40% and 5% respectively; we note that there is no correlation between values (p = 0.289) at Hr. 0; However at 24 hours a significant correlation (P = 0.000) is observed.
Conclusions: the base deficit should not be considered a reliable substitute for serum lactate at the beginning of resuscitation of patients with sepsis, severe sepsis and septic shock lactate; but it is likely useful after 24 hours.
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References
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