Usefulness of prothrombin and activated partial thromboplastin time in the preoperative assessment of hemostasis in pediatrics

Usefulness of PT and APTT in the preoperative assessment of hemostasis in pediatrics.

Authors

  • Raúl Copana Olmos 1Terapista Intensivo Pediátrico. Responsable Servicio de Terapia Intermedia, Hospital del Niño Manuel Ascencio Villarroel; Docente Investigador Posgrado, Universidad Mayor de San Simón; Sociedad Boliviana de Terapia Intensiva Pediátrica.
  • Mauricio Peralta Caballero Traumatologo. Jefe del departamento de Cirugía Pediátrica, Hospital del Niño Manuel Ascencio Villarroel.
  • Roberto Unzueta Quiroga Medico Salubrista. Departamento de planificación, Escuela Técnica de Salud. Ministerio de Salud Bolivia.
  • Gonzalo Carpio Deheza Cirujano General. Subdirector Médico, Hospital Clínico Viedma; Docente Investigador Posgrado, Universidad Mayor de San Simón.

Keywords:

screening, hemostasia, pediatric surgery, preoperative assesment

Abstract

To evaluate hemostasis preoperatively, a directed clinical history and physical examination are indicated, and the use of routine coagulation being recommended when there is some indication, and not routine; 

Objective: the present study aims to know the usefulness of PT and APTT in the preoperative assessment of coagulopathies in scheduled minor and outpatient surgeries.

Methods: A prospective, observational study was conducted in a tertiary surgical hospital; We select patients undergoing minor and outpatient procedures, excluding those with comorbidities, surgical risk of high bleeding, or with medication that interferes with coagulation.

Results: 69 patients were recruited, the clinical history and the directed physical examination were applied, identifying 1 patient suspected of coagulation disorder (later discarded); 218 complementary tests were performed: 69 routine (PT, APTT, blood count) and 149 non-routine (arbitrarily indicated), obtaining mean values in normal ranges and not being able to identify or rule out coagulation disorders with them, but observing 21% ( 15 cases) abnormal results (false positives), which additionally led to behaviors to confirm or correct these values, ranging from repeating the test to transfusing blood products; generating a global average cost of 102 Bs. per patient, without a benefit or change in clinical or surgical behavior.

Conclusion: the study established that routine preoperative screening tests have little utility and are little cost-beneficial in the assessment of the hemostasis for minor or outpatient procedures, compared to a history and directed physical examination; its indication being appropriate when there are abnormal findings in the physical examination and clinical history or based on concomitant diseases.

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References

Rapaport SI. Preoperative hemostatic evaluation: which tests, if any? Blood 1983.https://doi.org/10.1182/blood.V61.2.229.bloodjournal612229

Chee YL, Crawford JC, Watson HG, Greaves M. Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology. Br J Haematol 2008. https://doi.org/10.1111/j.1365-2141.2007.06968.x

Cosmi B, Alatri A, Cattaneo M, et al. Assessment of the risk of bleeding in patients undergoing surgery or invasive procedures: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res 2009. https://doi.org/10.1016/j.thromres.2009.08.005

De Paepe A, Malfait F. Bleeding and bruising in patients with Ehlers-Danlos syndrome and other collagen vascular disorders. Br J Haematol 2004. https://doi.org/10.3109/9780203997352.078

Velanovich V. The value of routine preoperative laboratory testing in predicting postoperative complications: a multivariate analysis. Surgery 1991.

Narr BJ, Warner ME, Schroeder DR, Warner MA. Outcomes of patients with no laboratory assessment before anesthesia and a surgical procedure. Mayo Clin Proc 1997. https://doi.org/10.1016/S0002-9394(14)70851-7

Velanovich V. Preoperative laboratory screening based on age, gender, and concomitant medical diseases. Surgery 1994. https://doi.org/10.1097/00132586-199410000-00026

Wattsman TA, Davies RS. The utility of preoperative laboratory testing in general surgery patients for outpatient procedures. Am Surg 1997.

Adams JG Jr, Weigelt JA, Poulos E. Usefulness of preoperative laboratory assessment of patients undergoing elective herniorrhaphy. Arch Surg 1992. https://doi.org/10.1001/archsurg.1992.01420070061012

Silver D. What Routine Preoperative Tests for Bleeding Tendencies? JAMA 1976.

Eisenberg JM, Clarke JR, Sussman SA. Prothrombin and partial thromboplastin times as preoperative screening tests. Arch Surg 1982. https://doi.org/10.1001/archsurg.1982.01380250030007

Kaplan EB, Sheiner LB, Boeckmann AJ, et al. The usefulness of preoperative laboratory screening. JAMA 1985. https://doi.org/10.1001/jama.1985.03350480084025

Segal JB, Dzik WH, Transfusion Medicine/Hemostasis Clinical Trials Network. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 2005. https://doi.org/10.1111/j.1537-2995.2005.00546.x

Wahlberg T, Blombäck M, Hall P, Axelsson G. Application of indicators, predictors and diagnostic indices in coagulation disorders. I. Evaluation of a self-administered questionnaire with binary questions. Methods Inf Med 1980. https://doi.org/10.1055/s-0038-1635279.

Laine C, Williams SV, Wilson JF. In the clinic. Preoperative evaluation. Ann Intern Med 2009. https://doi.org/10.7326/0003-4819-151-1-200907070-01006.

Copana R, Melean LG. Hiponatremia en pacientes postoperados en el Hospital del Niño Manuel Ascencio Villarroel, Cochabamba, Bolivia. Gac Med Bol. 2014.

Published

2020-12-30

How to Cite

1.
Copana Olmos R, Peralta Caballero M, Unzueta Quiroga R, Carpio Deheza G. Usefulness of prothrombin and activated partial thromboplastin time in the preoperative assessment of hemostasis in pediatrics: Usefulness of PT and APTT in the preoperative assessment of hemostasis in pediatrics. GMB [Internet]. 2020 Dec. 30 [cited 2025 Oct. 26];43(2):137-42. Available from: https://www.gacetamedicaboliviana.com/index.php/gmb/article/view/195

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Artículos Originales